The US major indices are closing sharply lower with the Nasdaq leading the way. The final numbers are showing: Dow fell -503.53 points or -1.43% at 34738.07 S&P fell -85.42 points or -1.90% at 4418.65 Nasdaq fell -394.48 points or -2.78% at 13791.16 Russell 2000 fell -21.01 points